Hi MBB,
You can delete all the files saved in your computer that is associated to PlayMemories Home by following these steps:
1. Uninstall and remove all directories
c:\Users\ACCOUNT\AppData\Roaming\Sony Corporation\ c:\Users\ACCOUNT\Documents\Sony PMB\ c:\Program Files (x86)\Sony\PlayMemories Home\
2. run regedit
3. remove keys HKEY_CURRENT_USER\Software\Sony Corporation\PMB
4. For each windows account a separate PMB database is stored in the registry - find all and delete keys
HKEY_USERS\S-1-5-21-278653546-428070248-3150906416
I would also suggest contacting your computer's support team to troubleshoot the drive that you're having issues with, since as you said, the software works in another drive.
Answered your question? Glad I could help! Please Click the "Accept as Solution" button below. Thanks_Mitch